Review Article

Microchimerism may be the cause of psychiatric disorders

Osman Demirhan* and Bülent Demirbek

Published: 02 December, 2019 | Volume 3 - Issue 1 | Pages: 042-046

Microchimerism is a bidirectional exchange of fetal and maternal cells during pregnancy (Figure 1). Pregnancy is the most common and natural cause of chimerism, and bi-directional trafficking of hematopoietic cells occurs through the placenta. Therefore, we are all born as microchimera [1,2]. Although there are many unanswered questions it is thought that chimerism has an important role in human health. For many years, the clinical effects of maternal microchimeric cells (MMcCs) in organ repair and cancer therapy have just begun to be understood. While the mission of chimerism is straight forward, the subject is profound. Chimerism carries the potential for disease as well as for health benefits. Recent studies have shown that maternal stress and infections in pregnancy affect fetal neuro development and increased the risk of neurological or psychiatric disorders in the future life of the fetus. This article describes the role of Mc in the etiology of psychotic disorders.

Read Full Article HTML DOI: 10.29328/journal.apmh.1001009 Cite this Article Read Full Article PDF


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Figure 1

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